CAR T-cell therapy may be harnessed to treat heart disease: Immunotherapy reduces cardiac fibrosis and restores heart function in mice after cardiac injury

CAR T-cell therapy, may be viable treatment option for CAR T-cell therapy life-threatening condition: heart disease. In first-of-its-kind study, at Penn Medicine used modified T to remove activated fibroblasts contribute to the development cardiac fibrosis -- process found in most heart disease in heart stiffness function the heart. The team found the significantly reduced cardiac fibrosis restored heart function in with heart disease caused high blood pressure. "The to harness patients' own to fight cancer has one the most research breakthroughs the decade," said the study's author Jonathan A.

The inhibition of SGLT-2 was not associated with an improvement in left ventricular (LV) reverse remodeling in patients with type 2 diabetes mellitus (T2DM), new study results suggest. “There is no known association between diastolic function parameters as determined by transthoracic echocardiography (TTE) and SGLT-2 inhibitor therapy,” the paper authors, publishing in meeting supplement of the Journal of Cardiac Failure and presenting at the Heart Failure Society of American Scientific Meeting in Philadelphia. “We hypothesized that in patients with T2DM the use left ventricular diastolic dysfunction treatment of SGLT-2 inhibitors might improve TTE diastolic function parameters including LV mass and LV mass index. ” The study was a retrospective chart analysis off 141 patients with T2DM who were prescribed SGLT-2 inhibitors in either the inpatient or outpatient setting in a single center between March 2013 and March 2018. TTE variables were evaluated at baseline and at one year following treatment. The authors used paired-t testing to explore changes brought about by SGLT-2 inhibition on TTE parameters after one year.

CAR T-cell therapy, may be viable treatment option for life-threatening condition: disease. In first-of-its-kind study, at Penn Medicine used modified T cells CAR T-cell therapy to and remove activated fibroblasts contribute to development cardiac fibrosis-;a scarring process in most forms disease results in stiffness and decreased function heart. The approach significantly cardiac fibrosis and restored function in mice with disease caused by high pressure. The ability to patients' own cells to cancer has been one most promising research past decade, marks significant step in our efforts to and potentially reverse condition accelerates SGLT-2 Inhibitors Fail progression failure.